A circular infographic showing the development timeline and strategic aspects of a feedstock project, including sections for integrated feedstock to SAF, cost/economic advantage, differentiated commercial model, and time to market, with a central logo labeled 'Crysalis'.

Strategy

Economic & Scale

Creation of scale & complexity in ethanol “refining” to reduce costs and volatility

  • Feedstocks: corn, sugar crops, starch crops, agricultural residues, food waste

  • Products:  Feedstock/intermediates into pharmaceutical (BioACN), chemicals/SAF sector (Cocura)

Potential addition of 10 bn gallons of product from existing feedstock

Scalable Commercial Model

  • Transparent revenue and cost stack collaboration with customer anchored on feedstock & Scope 3 markets

  • Leveraging significant HEFA feedstock access and relationships to 5x Cocura volumes 

  • Focus on “tolling” and JVs to accelerate time to market and reduce costs

  • Global focus with initial focus in Asia Pacific and Americas

Our R&D Center

At the heart of Crysalis innovation is our R&D and piloting center in Louisville, Colorado — a one-of-a-kind modular facility built by a team of former NREL scientists and engineers, many of whom spent over a decade advancing world-class renewable technologies. This highly flexible site is purpose-built to de-risk and scale up breakthrough bioprocesses, drawing on deep expertise developed at the nation’s leading energy lab.

Our team continues to collaborate closely with NREL as we pilot ultra-pure, bio-based solvents for pharmaceutical applications and advance the scale-up of Cocura™, our proprietary Sustainable Aviation Fuel technology. This facility isn’t just where we test ideas — it’s where they are brought to life.

Two engineers in hard hats and white lab coats work inside a testing facility with industrial pipes, valves, and control panels for scientific or engineering experiments.

Bio-based Acetonitrile

Bio-Acetonitrile is the world's first 100% bio-based, ultra-pure acetonitrile, specifically designed for the pharmaceutical and battery industries. Produced through a patent-protected process that combines microbial conversion of ethanol feedstock with chemical catalysis, Bio-Acetonitrile supports the corn ethanol industry of the American Heartland, eliminates hazardous byproducts like HCN, and achieves a ~90% lower carbon footprint compared to fossil-based alternatives.

Verified through GREET 2025 modeling and third-party consultants, our acetonitrile meets oligonucleotide-grade specifications without relying on mass balance accounting tricks. This ensures unmatched purity, safety, and sustainability while bolstering American agriculture and chemical industries.

A close-up view of a glass of beer with frothy bubbles on the surface.

Proprietary LCA & TEA Tools

At Crysalis, we’ve developed proprietary techno-economic analysis (TEA) and life cycle assessment (LCA) tools that set a new standard for evaluating and deploying low-carbon manufacturing. Built on deep expertise from our time at the National Renewable Energy Laboratory (NREL), our platform integrates GREET-based LCA modeling with ASPEN process simulations and real-time plant data. These tools allow us to precisely quantify Scope 1, 2, and 3 emissions reductions for any shuttered asset we evaluate — enabling rapid, data-driven decisions on where and how to implement our biomanufacturing technologies. As Crysalis scales, these tools not only guide our own growth but offer a powerful resource for any organization looking to decarbonize legacy infrastructure.

What’s next?

Our R&D team is continuously expanding the frontier of biomanufacturing. We’re developing new ultra-high purity, bio-based solvents tailored to pharmaceutical needs — building on the global ethanol infrastructure already in place. In parallel, we’re advancing novel Sustainable Aviation Fuel pathways and actively scouting new technologies to power the next generation of Crysalis facilities. As we prepare for Plants 2, 3, and beyond, our goal remains clear: transform dormant industrial assets into cutting-edge biorefineries with uniquely profitable, low-carbon product portfolios. Would you like to join our team? Click here for current job opportunities.

Two engineers wearing white lab coats and safety helmets working on a large industrial machine with pipes, gauges, and control panels.

Cocura SAF

Bio-Acetonitrile is the world's first 100% bio-based, ultra-pure acetonitrile, specifically designed for the pharmaceutical and battery industries. Produced through a patent-protected process that combines microbial conversion of ethanol feedstock with chemical catalysis, Bio-Acetonitrile supports the corn ethanol industry of the American Heartland, eliminates hazardous byproducts like HCN, and achieves a ~90% lower carbon footprint compared to fossil-based alternatives.

Verified through GREET 2025 modeling and third-party consultants, our acetonitrile meets oligonucleotide-grade specifications without relying on mass balance accounting tricks. This ensures unmatched purity, safety, and sustainability while bolstering American agriculture and chemical industries.

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Products

  • Feedstock Intermediates

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  • Sustainable Aviation Fuel

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  • Solvents

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